G protein simulations reveal how a critical signaling step works inside cells

UNC researchers discovered how a key step in cell signaling works by showing exactly how G proteins detach from receptors ...
EurekAlert!

Plants and people share a molecular signaling system, researchers discover

Scientists announce in the current issue of the journal Nature their discovery that plants respond to environmental stresses with a sequence of molecular signals known in humans and other mammals as ...
News Medical

G-Protein coupled receptors (GPCRs) and their role in targeted drug development

A number of membrane proteins that are present on the cell membrane control external and internal material transportation, cell protection and signal transmission. The diversity of functions of ...
GEN

In-Depth GPCR Signaling Characterization for Improved Drug Discovery

G protein–coupled receptors (GPCRs) play crucial roles in the regulation of a wide variety of physiological processes and represent one-third of targets with clinically prescribed drugs. Yet, it ...
Purdue University

Some opiates help mitigate fear, anxiety, manage pain

Key research finding: Pharmacologists are working to help mitigate the detrimental side effects of opiates, including addiction, respiratory depression, constipation and alcohol use. Many ...
GEN

Researchers Find that Some Antipsychotics Do Not Work as Effectively as Presumed

Assay tests documented in PNAS show that nine drugs block G-protein pathway inconsistently. Some antipsychotic drugs do not work as scientists have assumed, according to researchers from Duke ...
JSTOR Daily

Protein Pathway and Complex Clustering of Correlated mRNA and Protein Expression Analyses in Saccharomyces cerevisiae

Michael P. Washburn, Antonius Koller, Guy Oshiro, Ryan R. Ulaszek, David Plouffe, Cosmin Deciu, Elizabeth Winzeler, John R. Yates III Proceedings of the National ...

70-year-old blood pressure drug unlocks a new way to treat cancer

For more than 70 years, hydralazine has helped doctors lower dangerously high blood pressure during medical emergencies, ...
Purdue University

Some opiates help mitigate fear, anxiety, manage pain

Key research finding: Pharmacologists are working to help mitigate the detrimental side effects of opiates, including addiction, respiratory depression, constipation and alcohol use. Many ...