A number of membrane proteins that are present on the cell membrane control external and internal material transportation, cell protection and signal transmission. The diversity of functions of ...

GPCRs possess a heptahelical structure and support normal transmembrane cell signaling processes for growth and cellular development. They are mainly found in eukaryotes but have also been observed in ...

Lefkowitz started to trace cell receptors in 1968. Using radioactivity, he managed to unveil several receptors, including one for adrenalin, the β-adrenergic receptor. His team then extracted the ...

The researchers captured eight unique structural models and 16 cryogenic electron microscopy maps of the receptor with both ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 17 (Apr. 26, 2005), pp. 6027-6032 (6 pages) Recent studies suggest that lysophosphatidic acid (LPA) and ...

Studying the similarities between humans and mice is easy. Studying the differences can be almost impossible. Take the cerebral cortex. The highly folded, gyrencephalic human cortex has much evolved ...

Knowing that naloxone works by stalling the µ-opioid receptor in an early, latent state suggests that molecules that can bind more tightly or more selectively to this form of the receptor could be ...

Heterotrimeric G proteins are important in G protein-coupled receptor signaling, which is important in the detection of various stimuli. Here, researchers found that the protein that regulates ...

One-third of FDA-approved drugs target G protein-coupled receptors (GPCRs), transmembrane cell surface proteins that recognize small molecules and polypeptides with diverse chemical scaffolds. When a ...