Figure 2: Ligand-dependent and -independent phenotypes are induced by tissue-specific expression of a hRO-i, a G i RASSL. With the current DREADD-type RASSLs, only two point mutations were required to ...

The poster also demonstrates endogenous receptor activity in CHO-K1 and HEK-293 cell lines stably expressing the GloSensor plasmid. In addition, transfected Gs- and Gi-coupled receptor activity are ...

Researchers have discovered that a crucial communications pathway in cells not only stops cells from making proteins, it also makes them go. The team was able to define the way in which proteins ...

Ron O. Dror, Albert C. Pan, Daniel H. Arlow, David W. Borhani, Paul Maragakis, Yibing Shan, Huafeng Xu, David E. Shaw Proceedings of the National Academy of Sciences ...

A molecular 'rheostat' in the brain's appetite control center has been discovered that may provide new insights into obesity, which is at epidemic levels in the United States. The discovery of this ...

There are many and various receptors on the surface of each human cell, which bind to specific molecules called ligands, to set off signals that modulate cell activity accordingly. These pathways are ...

With approximately 30 to 40 percent of all marketed prescription pharmaceuticals acting on G protein-coupled receptors (GPCRs), these receptors remain attractive investigational drug targets, even ...

A multinational research team led by Dr. Adnan Sljoka (RIKEN), Prof. R. Scott Prosser (Univ. of Toronto) with collaborations with Dr. Duy Phuoc Tran and Prof. Akio Kitao (Tokyo Tech) and Prof. Roger K ...

Signal transduction is a key mechanism that brings about several physiological responses in a cell. Aberrant signaling can result due to gene mutations or regulatory protein overexpression. It is ...

G-protein-coupled receptors (GPCRs) remain major drug targets, despite an incomplete understanding of how they signal through 16 non-visual G-protein signal transducers (collectively named the ...