technologynetworks

Applications of EFC-based Protein-Protein Interaction Assays for Gi, Gs, and Gq-Coupled GPCR Screening

GPCR targets can be addresssed with a variety of technologies and they are increasingly being evaluated with multiple assay approaches. DiscoveRx has validated over 60 GPCR targets (Gi, Gs, Gq, Type A ...
BioWorld

TAAR1-Gs/Gq dual-pathway agonist shows superior antipsychotic-like activity in preclinical models

Trace amine-associated receptor 1 (TAAR1) is a member of the G protein-coupled receptor (GPCR) TAAR family, which has been shown to be enriched in the central nervous system and periphery. TAAR1 can ...
technologynetworks

Using the Promega GloSensor™ cAMP technology on the FLIPR® Tetra system for live cell Gi- and Gs- coupled GPCR second messenger assays

The poster also demonstrates endogenous receptor activity in CHO-K1 and HEK-293 cell lines stably expressing the GloSensor plasmid. In addition, transfected Gs- and Gi-coupled receptor activity are ...
technologynetworks

Specificity Mechanism Revealed When Glucagon Receptor Structures Solved

G protein-coupled receptors (GPCRs) play essential roles in cell signal transduction and serve as important therapeutic targets for a large number of diseases. Upon binding to extracellular agonists, ...