Here's what we know about the 2026 Florida Python Challenge, how the yearly hunt works and a little bit about last year's winner.

Scientists in Florida have launched a new offensive against the Burmese python invasion, this time using opossums, one of the giant snake’s favorite prey. The initiative comes from biologists A.J. Sanjar and Michael Cove of the Crocodile Lake National Wildlife Refuge in Key Largo, South Florida.

Have any humans have been killed by Burmese pythons? What to know Florida's large, invasive residents and their misconceptions

Are Florida's invasive Burmese pythons are more active in warmer months? Signs show signs of cold tolerance, potentially spreading north.

Carl Jackson caught a nearly 17-ft long Burmese python weighing over 200lbs as part of an effort to rid Florida of the invasive snake.