Signal transduction by GRB2 and SOS1. When some substances bind to a membrane receptor, a reaction occurs between the receptor and GRB2, which then goes on to bind and activate SOS1. SOS1 can then ...

GPCRs (G-protein-coupled receptors) represent the largest family of membrane receptors currently targeted by approved drugs. It is estimated that approximately 700 approved drugs target GPCRs ...

There are many kinds of T cells, and they play different parts in defending the body. Some T cells kill infected cells, ...

A revolution has occurred in the field of pharmaceutical development due to the development of drugs that target membrane proteins. It is estimated that one-third of currently available drugs target G ...

Cardiovascular diseases remain a leading cause of death around the world. A primary contributor to these afflictions is high blood pressure, or hypertension. While treatments exist for the condition, ...

The group of Prof. Dr. Ralf Erdmann at the Ruhr-Universität Bochum, Germany, discovered a connection of peroxisomal protein import and receptor export. In the Journal of Biological Chemistry, they ...