Thanksgiving Day football starts off with an NFC North rivalry. This is matchup is a great way to start the holiday. The Packers are 7-3-1 while the Lions are 7-4, but both trail the Chicago Bears who are 8-3 and lead the division. This is a tough game to predict, as most divisional games are, but I’ll be taking the Lions at home in this one.

We're diving into every matchup in Week 13 of the 2025 NFL season â?? including key storylines, matchups to watch, and injury news. The Green

NFL Week 13 picks, predictions, win probabilities for Packers-Lions, Rams-Panthers, Texans-Colts, Vikings-Seahawks, Raiders-Chargers, games this week.

NFL Week 13 features a 16-game slate, including a number of key divisional matchups. Among the biggest is when the Green Bay Packers battle the Detroit Lions in an NFC North matchup on Thanksgiving Day.

USA Today's NFL experts make their picks for a Week 13 showdown between the Detroit Lions and Green Bay Packers

One of those games happened in Week 1. The Lions were demolished by the Green Bay Packers. They lost 27-13, and the score only looked that good because Detroit got a touchdown in garbage time. Green Bay thoroughly outplayed them. Like the Lions, the Packers have had trouble consistently playing at that level since.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 13 on a 49-33 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

USA Today's NFL experts make their picks for a Week 13 showdown between the Los Angeles Chargers and Las Vegas Raiders

Here's everything you need to know when the New York Giants play the New England Patriots Week 13 of the 2025 NFL season.