EurekAlert!

Regulation of the Canonical and Non-Canonical NF-κB Pathways (IMAGE)

The diagram depicts negative feedback mechanisms via IκB proteins and A20 in the canonical pathway, and IKKα onto NIK in the non-canonical pathway. There are cross-talk mechanisms such as NIK ...
EurekAlert!

Nobel Laureate David Baltimore reviews NF-κB research: Mastering cell fate, regulating health and disease

The diagram depicts negative feedback mechanisms via IκB proteins and A20 in the canonical pathway, and IKKα onto NIK in the non-canonical pathway. There are cross-talk mechanisms such as NIK ...
BioWorld

New inhibitor of the noncanonical NF-κB pathway specifically binding to RelB shows antitumor effect

The transcription factor nuclear factor-κB (NF-κB) family has a central regulatory role in the expression of many genes related to immune responses, inflammation, cell survival and cancer. Previous ...
news.ucsb.edu

A new synergistic method can create non-canonical amino acids by merging synthetic photochemistry with biocatalysis

New chemistry, new enzymology. With a new method that merges the best of two worlds — the unique and complementary activities of enzymes and small-molecule photochemistry — researchers at UC Santa ...