Notch signalling is a highly conserved cellular interaction pathway fundamental to metazoan development and homeostasis. When notch, a cell-surface receptor, binds to a ligand on a neighboring cell, ...

Researchers at Karolinska Institutet in Sweden have used DNA origami, the art of folding DNA into desired structures, to show how an important cell receptor can be activated in a previously unknown ...

Researchers have used DNA origami, the art of folding DNA into desired structures, to show how an important cell receptor can be activated in a previously unknown way. The result opens new avenues for ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

Chimeric antigen receptor (CAR) T cell therapy is a promising immunotherapy against cancer. The idea is to fortify a person’s immune system to fight its own battle by boosting T cells with the ability ...

A collaborative study provides compelling evidence that combining an investigational oral drug with standard-of-care medications reverts hormone resistance and increases Rx effectiveness in ...

The human skeleton provides support, facilitates movement, and protects many internal organs in the body. However, as people age, their bones become weaker and more prone to fractures that take longer ...

These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com N. Gupta-Rossi et al ...