Nuclear receptors are popular targets for drug companies searching for new therapeutics for cancer and cardiovascular, metabolic, inflammatory, and other diseases. Indigo Biosciences in State College, ...

Nuclear receptors are receptors that bind to a ligand that has crossed the cell membrane, after which the ligand-bound receptor binds to DNA to regulate gene expression. These receptors are key ...

Looking at this website reminds me of the tremendous amount of progress we’ve made at the biological and computational level. Who would have thought 20 years ago that there would be a discipline of ...

Metabolic dysfunction-associated steatotic liver disease (MASLD), affecting approximately 30% of the global population, represents a spectrum of liver disorders ranging from simple steatosis to ...

Orphan nuclear receptors influence the onset and progression of MASLD, particularly in lipid metabolism, inflammation, autophagy, and cholesterol metabolism. These receptors may play either similar or ...

Image Caption: Epigenetic regulation of receptors. Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 50 (December 13, 2022), pp. 1-10 (10 pages) Efforts to decrease the adverse effects of nuclear receptor ...

Researchers have found a compound in ginger, called furanodienone (FDN), that selectively binds to and regulates a nuclear receptor involved in inflammatory bowel disease (IBD). While researchers have ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 39 (September 29, 2020), pp. 24392-24402 (11 pages) Enhancing long-term persistence while simultaneously ...

Phase III Randomized Study of Cisplatin Versus Paclitaxel Versus Cisplatin and Paclitaxel in Patients With Suboptimal Stage III or IV Ovarian Cancer: A Gynecologic Oncology Group Study PURPOSE: To ...

Detailed price information for Olema Pharmaceuticals Inc (OLMA-Q) from The Globe and Mail including charting and trades.