Perhaps no topic is hotter in Alzheimer disease molecular research today than the synaptic effects of amyloid-β (Aβ) oligomers. These toxic assemblies disrupt synaptic function, and are leading ...
Professor Suh Byung-chang's research team of the Department of Brain Sciences, DGIST (President: Kuk Yang), announced on Wednesday, November 23 that they have identified the molecular mechanism for ...
Mutations in presenilin associated with familial Alzheimer disease perturb calcium signaling in cells. In particular, some mutations suppress capacitative calcium entry (CCE), the mechanism for ...
Inositol trisphosphate receptors (IP3Rs) are pivotal Ca²⁺ channels embedded in the membrane of the endoplasmic reticulum. Their activation by inositol 1,4,5-trisphosphate (IP3) and Ca²⁺ gives rise to ...
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