Researchers at National Taiwan University have uncovered, for the first time at atomic resolution, how the human proteasome ...

Cancer cells are more dependent on a cellular garbage disposal unit -- the proteasome -- than healthy cells, and cancer therapies take advantage of this dependency. Scientists have determined the ...

The core particle (CP) of the yeast proteasome is composed of four heptameric rings of subunits arranged in a hollow, barrel-like structure. We report that the CP is autoinhibited by the N-terminal ...

Protein degradation in eukaryotic cells is performed by the Ubiquitin-Proteasome System (UPS). The 26S proteasome holocomplex consists of a core particle (CP) that proteolytically degrades ...

Targeted protein degradation (TPD) approaches including PROTAC and molecular glue have revolutionized drug discovery. However, in part due to complication of the ubiquitination and related ...

Malignant cancer cells not only proliferate faster than most healthy cells in our bodies. They also generate more "junk", such as faulty and damaged proteins. This makes cancer cells inherently more ...

There is an urgent need for new antimalarial drugs because the malaria parasite has developed resistance to the most widely used therapies—combinations of artemisinin and other drugs—and most ...

Success as An Anti-Cancer Agent Has Fueled Efforts to Discover Proteasome Inhibitors That Raise Proteins Levels with Beneficial Effects The ubiquitin proteasome system (UPS) provides a mechanism for ...

Phase II results of Study PX-171–007: A phase Ib/II study of carfilzomib (CFZ), a selective proteasome inhibitor, in patients with selected advanced metastatic solid tumors ...

Our ever-increasing understanding of cancer cell biology has begun to provide a variety of new, and potentially drugable targets for the treatment of many forms of cancer. Nowhere else is this more ...

Like a woolly mammoth in a tar pit, proteasomes may be doomed if they get stuck in gobs of the DNA-binding protein TARDP, better known as TDP-43. That’s according to new research from the labs of ...