As a result, they play an extremely important role in metabolism. Individual enzymes frequently form a complex with many subunits, as in the case of the pyruvate dehydrogenase complex.

Indications: Pyruvate dehydrogenase complex deficiency, typically associated with post-prandial lactic acidemia with a normal lactate/pyruvate ratio, can be assayed in freshly isolated blood ...

The pyruvate dehydrogenase complex (PDC) in pea (Pisum sativum L., cv. Little Marvel) was studied immunologically using antibodies to specific subunits of mammalian PDC. Pea mitochondria and ...

The FDA has accepted for Priority Review the NDA for SL1009 to treat pyruvate dehydrogenase complex deficiency.

The study found that among the genes encoding components of the pyruvate dehydrogenase complex, which controls acetyl CoA synthesis, only dlat-1 and dld-1 expressions were decreased by 6-PPDQ.

The pyruvate dehydrogenase complex has been purified 76-fold, to a specific activity of 0.6 μmoles per minute per milligram protein, beginning with isolated pea (Pisum sativum L. var Little Marvel) ...

Lily Cieslinski was diagnosed with Pyruvate Dehydrogenase Complex Deficiency in 2024. Her parents held a fundraiser to support research just two months later.