Advanced Tools to Investigate All Compound Classes of GPCR Activation Among targets of interest for the pharmaceutical industry, GPCRs account for more than 30% of all drug screenings. The complexity ...

A new study describes the development of a cAMP analogue that specifically activates only Epac2, one of several cAMP-responsive proteins. Furthermore, the analogue activates Epac2 more potently than ...

Extracellular signals are relayed to the cell’s interior by second messengers such as cyclic AMP (cAMP), which was once thought to diffuse freely throughout the cytoplasm. Yet cAMP has also become ...

RNA transcripts containing the hammerhead ribozyme have been engineered to self-destruct in the presence of specific nucleoside 3′,5′-cyclic monophosphate compounds. These RNA molecular switches were ...

Scientist have created photosensitive mimics of a class of signaling molecules, thus enabling their actions to be regulated by light, and affording new insights into the communications networks that ...

Ceramide has been proposed as a second messenger for stress-induced apoptosis. By characterization of murine melanoma cells and their E1A transfectants, we found several lines of evidences against the ...