AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis that modulates numerous metabolic pathways. Despite substantial interest in therapeutically targeting AMPK — ...

Isomeranzin (ISM) binds to Gnas, activating adenylyl cyclase and elevating intracellular cAMP levels. This activation ...

AMP-activated protein kinase (AMPK) is a highly conserved sensor of low intracellular ATP levels that is rapidly activated after nearly all mitochondrial stresses, even those that do not disrupt the ...

Adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays an important role in cellular energy homeostasis, helping in growth regulation and metabolic reprogramming in eukaryotes. The AMPK ...

Berberine, a natural compound from plants like Berberis, is gaining attention for its metabolic benefits. It helps manage ...

Long thought to suppress cancer by slowing cellular metabolism, the protein complex AMPK also seemed to help some tumors grow, confounding researchers. Now, Salk Institute researchers have solved the ...

A new study describes how hyperactivation of AMP-activated protein kinase promotes neurodegeneration in Huntington's disease. A new study describes how hyperactivation of AMP-activated protein kinase ...

Postoperative cognitive dysfunction is associated with neuronal apoptosis, which may result from post-surgery inflammation, the phosphorylation of tau protein and the accumulation of amyloid in aged ...

Most breast cancers utilize the female hormone estrogen to grow, so drug-induced estrogen deprivation is used as a treatment in many patients. However, cancer will recur in one-third of these patients ...

A new study describes how hyperactivation of AMP-activated protein kinase (AMPK) promotes neurodegeneration in Huntington's disease (HD). The article appears online on July 18, 2011, in The Journal of ...