Tamil Nadu Health Minister Ma Subramanian inspected a health center in Kodaikanal to assess the 'Loading Dose' scheme's ...

Synthetic improvements in the preparation of clopidogrel are described. The synthesis was accomplished in four steps or one-pot in above 70% overall yield. The process featured PTC catalyzed alkaline ...

DAPT consisting of aspirin and clopidogrel beyond 12 months has been shown to reduce the risk of MI not related to stented segments. 18 The benefits and risks of aspirin and ticagrelor at doses of 60 ...

Abstract A series of optically active 2-hydroxytetrahydrothienopyridine derivatives were designed and synthesized as prodrugs of clopidogrel thiolactone in order to overcome clopidogrel resistance.

In patients who received omeprazole in addition to aspirin and clopidogrel, the mean PRI at day 7 was 51.4 ± 16.4%, compared with 39.8 ± 15.4% in those who received aspirin and clopidogrel alone ...

Dr. Sabatine: Clopidogrel is a prodrug and it needs to be activated through sequential oxidative steps in the liver (Slide 1). There is another pathway where esterases can take that pro-drug and ...

As generic versions of AstraZeneca’s blockbuster drug ticagrelor prepare to enter the market, The BMJ raises fresh concerns over the integrity of the clinical trials that underpinned its approval.

D illustration of a blood vesselLakshmiraman Oza/Pixabay Blocked leg arteries - often caused by diabetes or smoking - are very common, but if left ...

Compared with aspirin, clopidogrel reduces risk of mortality, myocardial infarction (MI), and stroke after percutaneous coronary intervention (PCI) and completion of a standard duration of dual ...

Among the 4,353 patients included in the 30-day landmark analysis, 1,711 had HBR and 2,457 had STEMI. Compared with clopidogrel, the crude hazard ratios (HRs) for aspirin were not statistically ...