Figure 2: Ligand-dependent and -independent phenotypes are induced by tissue-specific expression of a hRO-i, a G i RASSL. With the current DREADD-type RASSLs, only two point mutations were required to ...

The poster also demonstrates endogenous receptor activity in CHO-K1 and HEK-293 cell lines stably expressing the GloSensor plasmid. In addition, transfected Gs- and Gi-coupled receptor activity are ...

Recent years have seen an explosion of disease-relevant research on G-protein coupled receptors (GPCRs). Hot topics include strategies for targeting GPCRs therapeutically, and understanding the ...

A molecular 'rheostat' in the brain's appetite control center has been discovered that may provide new insights into obesity, which is at epidemic levels in the United States. The discovery of this ...

After Jonathan Violin completed his Ph.D. at the University of California, San Diego, he wanted to continue his research with a high-profile scientist working on G-protein-coupled receptors (GPCRs).

Then, on Aug. 4, 2000, structural biologists published the first X-ray structure of a GPCR. That day, an elated Topiol charged into a meeting, the journal article held aloft. “It was all very exciting ...

G-protein coupled receptors (GPCRs) are seven-pass transmembrane proteins involved in numerous signaling pathways. Upon extracellular ligand binding and activation, members of this superfamily mediate ...

There are many and various receptors on the surface of each human cell, which bind to specific molecules called ligands, to set off signals that modulate cell activity accordingly. These pathways are ...

Have you ever wondered how drugs reach their targets and achieve their function within our bodies? If a drug molecule or a ligand is a message, an inbox is typically a receptor in the cell membrane.