By putting a carbon atom in place of a core oxygen, chemists constructed an opioid that blocks pain with less respiratory ...

Controlling regioselectivity remains one of the major challenges in hydrocyanation. When an unsymmetrical alkyne undergoes this reaction, it typically yields a mixture of regioisomers. This ...

A systematic survey of archived protein structures has revealed dozens of examples of a previously overlooked covalent bonding motif. Mapping these nitrogen–oxygen–sulfur (NOS) linkages could open the ...

"Our results demonstrated that the combination of β-sheet amide hydrogen bond formation and metal cross-linking of side chains limits the number of possible isomers.

A research team has successfully developed a new approach to create switchable magnetic materials by using hydrogen bonding at the molecular level. This groundbreaking study shows how certain ...

Hydrogen is not a metal on Earth, but scientists keep trying to create metallic hydrogen under high pressure to unlock a new superconductor.

The halogen bonding motif combined with a good STD signal of a hydrogen atom directly adjacent to the halogen was used as the primary criterion for hit prioritization (Figure 2C). In addition, we ...

An inter-helical carboxylate-hydroxyl hydrogen-bond motif is present at functionally important sites of membrane proteins from archaea to the brain. External carboxylate-containing H-bond clusters are ...

A hydrogen bond is an electrostatic attraction between an atom and the positive charge of a hydrogen atom covalently bound to something else. It is weaker than a covalent bond and can be either ...