Quaid's leading role in Novocaine feels like a natural continuation of these genre-bent everymen. He plays Nathan Caine, a mild-mannered assistant bank manager who has congenital insensitivity to pain with anhidrosis (CIPA), a genetic disorder that impacts his nervous system to the point that he can't feel pain or temperature.

Jack Quaid and Amber Midthunder are “dialed in,” making the romantic side of Novocaine work. As previously reported, the Paramount Pictures film Quaid stars as Nate, a regular guy — except for one thing: he can’t feel physical pain.

The hero at the heart of “Novocaine” can't feel pain. The new film in theaters Friday stars Jack Quaid as Nate, an ordinary guy whose disability becomes his saving grace when attempting to save a hostage from violent criminals.