Open-access platform explores epigenetic regulation of plant long non-coding RNAs

Long non-coding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides that do not code for proteins. Once considered mere transcriptional noise, lncRNAs are now known to play vital roles in ...

Plant 'first responder' cells warn neighbors about bacterial pathogens

Purdue University researchers found that a subset of epidermal cells in plant leaves serves as early responders to chemical cues from bacterial pathogens and communicate this information to neighbors ...

From body ache to oxidative stress: 5 teas that can help reduce inflammation

The human body experiences various health problems because of inflammation, which can lead to joint pain, heart disease and ...
The EMBO Journal

Identification of p38 MAPK inhibition as a neuroprotective strategy for combinatorial SMA therapy

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Spinal muscular atrophy (SMA) is a ...
Frontiers

Mechanisms of the JNK/p38 MAPK signaling pathway in drug resistance in ovarian cancer

1 Department of Obstetrics and Gynecology, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China 2 Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang ...
AOL

The 8 Best Ground Covers to Plant Between Pavers to Enhance Pathways and Patios

Planting ground covers between pavers can add a delicate, organic element to your patios, walkways, and garden borders. However, doing so requires plants that are low-growing, sturdy enough to stand ...
EurekAlert!

Ligustroside derived from Ligustrum japonicum inhibits melanogenesis via blocking the MAPK and PKA/CREB signaling pathways

Mitogen-activated protein kinase (MAPK) and Wnt signaling pathways are critical for melanocyte development and melanogenesis and could be novel therapeutic targets for modulating melanin synthesis.
C&EN

MAPK-CncC Signaling Pathways Regulate the Antitoxic Response to Avermectin-Induced Oxidative Stress in Juvenile Chinese Mitten Crab, Eriocheir sinensis

Key Laboratory of Application of Ecology and Environmental Protection in Plateau Wetland of Sichuan, Xichang University, Xichang 415000 Sichuan Province, China Key Laboratory of Animal Disease ...
C&EN

Blocking the p38 MAPK Signaling Pathway in the Rat Hippocampus Alleviates the Depressive-like Behavior Induced by Spinal Cord Injury

Department of Neurosurgery, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, No. 152 Aiguo Road, Nanchang, Jiangxi 330006, China Department of ...
Business Wire

Verastem Oncology Outlines 2025 Strategic Priorities and Milestones for Novel Pipeline Targeting RAS/MAPK Pathway-Driven Cancers

Avutometinib plus defactinib granted priority review by FDA, under the accelerated approval pathway, for recurrent KRAS mutant LGSOC; PDUFA action date set for June 30, 2025 Potential U.S. commercial ...
Frontiers

β-caryophyllene sensitizes hepatocellular carcinoma cells to chemotherapeutics and inhibits cell malignancy through targeting MAPK signaling pathway

Background: β-caryophyllene (BCP) is a naturally occurring bicyclic sesquiterpene extracted from various plants, and widely used as a medicinal agent for various diseases. During hepatocellular ...