A study by the Center for Redox Processes in Biomedicine (Redoxoma) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil) presents a valuable new experimental model for investigating ...

XtalPi has accrued a number of Big Pharma partners over the years, including Eli Lilly, which struck a $250 million deal in 2023 to use XtalPi’s tech to identify potential drug candidates that Lilly ...

Porcine reproductive and respiratory syndrome virus (PRRSV) continues to devastate the global swine industry, yet the ...

An article published in the journal Nature Metabolism presents an experimental drug that stimulates adipose tissue cells to ...

Isolated map and molecular model of the eIF3 PCI‐MPN core color coded as in Fig 2. Structural hallmarks are indicated, and a scheme shows the composition of the lobes. B, C. ... (PDB 5LL6, Heuer et al ...

The molecular_analysis directory contains scripts and notebooks for performing molecular dynamics analysis, constructing and analyzing Markov State Models (MSM), and setting up and analyzing Brownian ...

A model is presented for the chemomechanical coupling of kinesin motors, which proposes that the rate constants of the chemical reaction are independent of the external force. On the basis of the ...

EEA1-Rab5 Molecular Motor. Motor proteins are remarkable molecular machines within a cell that converts chemical energy, stored in a molecule called ATP, into mechanical work. The most prominent ...

The Brownian ratchet model is widely accepted among the molecular machinists. But Aprahamian points out that if a fuel molecule’s primary role is not to supply energy to make a molecular motor ...

Using single-molecule FRET spectroscopy and detailed structural information from coarse ... 10 mM MgCl 2, 1 mM ATP, 10 mM DTT, pH 7.5) were added and the mixture incubated at 85°C for 3 min. After ...

The complex is formed of several proteins that bind to a small molecule called ATP, whose arrival and subsequent breakdown release energy. Cohesin also interacts with DNA in a different way: it can ...