WEST LAFAYETTE, Ind. - A Purdue University study shows that Notch signaling, a key biological pathway tied to development and cell communication, also plays an important role in the onset of obesity ...

Notch signalling is a highly conserved cellular interaction pathway fundamental to metazoan development and homeostasis. When notch, a cell-surface receptor, binds to a ligand on a neighboring cell, ...

The Notch signaling system links cellular fate to that of its neighbors, driving proliferation, apoptosis, and cell differentiation in metazoans, whereas dysfunction leads to debilitating ...

Delta-like ligand-3 (DLL3) is a single-pass, type I transmembrane protein that inhibits the Notch signaling pathway. A highly conserved intercellular signaling pathway, the Notch signaling pathway ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

Researchers have used DNA origami, the art of folding DNA into desired structures, to show how an important cell receptor can be activated in a previously unknown way. The result opens new avenues for ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

This listicle explores how cancer hijacks key cell signaling pathways such as PI3K, MAPK and Notch to drive tumor growth, ...

The loss of muscle mass, or muscle atrophy, is a relatively common condition in today’s aging and increasingly sedentary societies. While the disuse of muscles is the most frequent catalyst for muscle ...

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by differences in communication, behavior and ...