It has been demonstrated that the presence of lymph node metastasis in patients with muscle invasive bladder cancer indicates a poorer prognosis compared with patients without lymphatic spread. [3] ...

Blastic plasmacytoid dendric cell neoplasm (BPDCN) is a rare, aggressive blood cancer that often involves the bone marrow, skin and, sometimes, lymph nodes. First-in-class antibody-drug conjugate ...

Background: BPDCN is a rare, clinically aggressive hematological malignancy primarily involving the skin, bone marrow, and lymph nodes. CD123 (IL-3Rα) is highly overexpressed on the surface of all ...

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a type of blood cancer that affects immune system cells. It most often affects the skin but can also involve bone marrow and other cell types.

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What you see is there's a large discrepancy. For example, around 8% or 9% of patients are thought to have cancer in their lymph nodes prior to surgery. When patients with plasmacytoid cancer undergo ...

Background Type 1 interferons (IFN-1) are major drivers of disease activity in systemic (SLE) and cutaneous lupus erythematosus (CLE). Plasmacytoid dendritic cells (pDCs) are the major producers of ...

A swollen lymph node can be a bit like your body’s version of a red flag: When one of these bean-shaped clusters of immune cells in your neck, armpit, or groin puffs up, it’s typically an ...

Summary: Plasmacytoid dendritic cells (pDCs) represent a specialized subset of dendritic cells (DCs) known for their role in producing type I interferons (IFN-I) in response to viral infections. It ...

Author response: The following is the authors’ response to the original reviews. Public Reviews: Reviewer #1 (Public Review): Summary: Plasmacytoid dendritic cells (pDCs) represent a specialized ...

Possible approach for therapies As pDCs also play a role in defending the body against viral pathogens and can be activated by viral infections accordingly, this is where we find a previously ...