Researchers at National Taiwan University have uncovered, for the first time at atomic resolution, how the human proteasome ...

A team of researchers from Academia Sinica and National Taiwan University has identified the Drosophila Cul2 substrate ...

Assembly of the 34-subunit, 2.5 megadalton 26S proteasome starts with formation of the seven-membered α-ring. A set of newly identified proteasome chaperones serves as a clamp to seal α-rings with the ...

GSK plc will present new data from its haematology portfolio at the 67th American Society of Hematology (ASH) Annual Meeting and Exposition (6 - 9 December), reinforcing its potential to redefine ...

As we get older, our brains start to change in ways that make them increasingly vulnerable to disease – and a detailed new ...

When blood cancer in children progresses particularly aggressively, it is often due to a genetic defect: a gene fusion, such ...

Booster Therapeutics is developing a novel therapeutic approach that aims to combat the accumulation of deviant proteins in cells, which are a major driver of Parkinson's and other complex diseases ...

As we age, the composition and function of proteins in the brain change, affecting how well our brain performs later in ...

Insilico's generative AI platform, Chemistry42, successfully designed a first-in-class PROTAC targeting PKMYT1 by creating an entirely new inhibitor and its complex linker, demonstrating a powerful, ...

Molecular glues are revolutionizing cancer therapy by targeting undruggable proteins for degradation, enhancing precision ...

Kelonia Therapeutics only started human testing of its in vivo CAR-T therapy for multiple myeloma in August, but already has ...