The protein, TDP-43, is cleaved, hyperphosphorylated, and ubiquitinated in inclusion bodies in both frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic ...

Inclusion bodies, once considered a hindrance in recombinant protein production, are now recognised for their potential as reservoirs of bioactive proteins and functional biomaterials.

Scientists routinely express heterologous proteins in Escherichia coli. However, these proteins may not fold properly in the bacteria, causing them to aggregate and form insoluble inclusion bodies.

Courtesy of Steven FinkbeinerInclusion bodies play a protective, not pathogenic, role in Huntington disease, according to a recent study by Steven Finkbeiner of the Gladstone Institute of Neurological ...

Artificial 'inclusion bodies' created for controlled drug release. Universitat Autonoma de Barcelona. Journal Advanced Science DOI 10.1002/advs.201902420 ...

Refolding, however, is frequently the rate- and yield-limiting step for protein production and purification. In addition to inclusion bodies, more and more therapeutic proteins are solubly ...

The artificial protein granules developed, which had previously been proposed as "nanopills" (therapeutic pills at nanoscopic scale), imitate the action of bacterial inclusion bodies and have ...

Formation of inclusion bodies follows on the inadequate clearance of the soluble proteins. Experiments in mice with an inducible liver-specific loss of Atg5 supported this idea, as those mice also ...