The research reveals significant reduction in the citric acid cycle intermediates and key enzyme gene expressions by 6-PPDQ ... Acetyl CoA generated from pyruvate is a key substrate for the cycle.

Men lose more weight than women on a ketogenic diet, according to a comprehensive review in Frontiers in Nutrition. Sex ...

As pyruvate was used as the denominator to calculate TCA cycle metabolite ratios, we extended our analysis to lactate since pyruvate is converted to lactate by lactate dehydrogenase. Cells in Cluster ...

Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS. Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle. Cell ...

As a result, cell death in IBD may activate other cell death processes, and in the presence of an inflammatory environment, the vicious cycle of cell death persists. IBD-related necroptosis mostly ...

Supramolecular assembly of enzymes into metabolon structures is thought to enable efficient transport of reactants between active sites via substrate channeling. Recombinant versions of porcine ...

Each reaction of the genes in glycolysis, PPP, the TCA cycle, and the glutaric acid biosynthetic pathway was gradually increased from the minimum flux to the maximum flux while maximizing glutaric ...