HOW Does 6-PPDQ disrupts the citric acid cycle in caenorhabditis elegans. FAYETTEVILLE, GA, UNITED STATES, July 2, 2025 /EINPresswire / ...

Of these, cells in Cluster 4 had high ratios of TCA cycle metabolites relative to pyruvate, produced more lactate yet consumed less glucose and glutamine, and greater OXPHOS activity compared to ...

Since the TCA cycle is an essential hub where various pathways converge and is critical for energy and biomass production and cell viability (Spinelli and Haigis, 2018) (Fig. 3A), we chose to contrast ...

In addition to Acetyl-CoA, another important central species is pyruvate (CH 3 COCOO –), which is found in multiple metabolic pathways, notably in the reductive TCA cycle, as well as in pathways ...

Working model revealing the role of ALDH4A1 in maintaining an active MPC complex for mitochondrial pyruvate import and TCA cycle entry. Credit: Nature Cell Biology (2025). DOI: 10.1038/s41556-025 ...

ALDH4A1 stabilizes the MPC complex, ensuring efficient delivery of pyruvate into the mitochondria. In the absence of ALDH4A1, this transport mechanism collapses.

CPI-613 (devimistat), a novel systemic therapeutic that targets the TCA cycle by inhibiting pyruvate dehydrogenase (PDH) and ketoglutarate dehydrogenase (KGDH), was used to treat HNSCC cells. MOC2 ...

The results showed that distinct metabolic phenotypes were identified among various infectious causes of ARDS. Metabolomic disparities between ARDS cases associated with COVID-19 and H1N1 were evident ...

The first step (glucose to pyruvate) is called anaerobic metabolism, the second step (pyruvate to CO2) is aerobic metabolism (as shown in the infographic above). We can also use fatty acids to ...