Why important genes 'go quiet' as we get older

The human gut renews itself faster than any other tissue: every few days, new cells are created from specialized stem cells.
European Medical Journal

Immunotherapeutic Strategies Based on CAR-T Cells in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the sixth leading cause of cancer-related mortality worldwide.1 Despite therapeutic ...
AlphaGalileo

As our gut age: New study finds out why important genes “go quiet” as we get older

Researchers from the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena, Germany, the Molecular Biotechnology ...
News-Medical.Net on MSN

Epigenetic drift explains why the aging intestine becomes more vulnerable to cancer

Researchers from the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena, Germany, the Molecular Biotechnology ...

Nature Communications | Insilico Medicine Presents AI-empowered Dual-Action PROTAC Targeting PKMYT1

Insilico's generative AI platform, Chemistry42, successfully designed a first-in-class PROTAC targeting PKMYT1 by creating an entirely new inhibitor and its complex linker, demonstrating a powerful, ...
eLife

E(spl)m4 Directly Antagonizes Traf4 to Inhibit JNK Signaling in Drosophila

The authors identify the Bearded-type small protein E(spl)m4 as a physical and genetic interactor of TRAF4 in the Drosophila wing disc. These valuable findings with potential biomedical relevance are, ...
The Lancet

Current and emerging therapeutic landscape for metabolic dysfunction-associated steatohepatitis

Globally, metabolic dysfunction-associated steatotic liver disease (MASLD) is now the most common chronic liver disease, affecting up to one in three people in the general population, with an ...