Researchers say this is the first combination therapy that targets two different cancer survival mechanism: PARP and WNT signaling.

Researchers at the University of Colorado Cancer Center have discovered a novel therapy combination that could offer new hope ...

Phase I/II study of the selective PI3Kβ inhibitor GSK2636771 in combination with pembrolizumab in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) and PTEN loss. Biallelic ...

The canonical Wnt signaling pathway. The left panel (A) demonstrates the activated Wnt signaling cascade, while the right side portrays the inhibited Wnt signaling cascade. Wnt binds to the Fz ...

FDA fast track designation facilitates expedited development of DPTX3186, recognizing its potential to address serious unmet ...

A specific form of epigenetic aging, ACCA drift, accumulates in intestinal stem cells, silencing key genes through hypermethylation. Driven by age-related inflammation, weakened Wnt signaling and ...

Developing peptide-based tools to fine-tune growth signaling pathways, in particular molecules with exquisite selectivity and high affinities, opens up opportunities for cellular reprogramming in ...