MicroRNA-33a and microRNA-33b are encoded within the mammalian SREBF1 and SRBF2 genes, respectively, and both SREBF1 and ...

Phosphatidylserine (PS) is a phospholipid mainly enriched in the inner leaflet of the plasma membrane; however, its role in the nucleus remains unclear. This study describes the presence of PS in the ...

Oocytes, female germ cells that develop into eggs, are among the longest-lived cells in the animal body. Recent studies on mouse oocytes highlight unique adaptations in protein homeostasis ...

These findings highlight the dual roles of antioxidants in cancer. Their impact depends on cancer type, stage, and genetic alterations. In tumors where redox-sensitive signaling promotes cell death, ...

imageimageThere are no cellular or molecular biomarkers diagnostic of myalgic encephalomyelitis (also known as chronic fatigue syndrome [ME/CFS]). We find hundreds of blood-based traits are different, ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. This study presents and characterizes a Dnmt3a ...

Algorithms that constrain metabolic network models with enzyme levels to predict metabolic activity assume that changes in enzyme levels are indicative of flux variations. However, metabolic flux can ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Studying the human immune system in vivo is ...

imageimageThe balance between cellular energy demand, expenditure, and anabolic processes to meet cells fundamental requirements remains debated. Using integrated temporal metabolomics and lipidomics, ...

How loss of KIF4A chromokinesin reduces chromosome association of condensin has remained unclear. This study demonstrates that human condensin I is auto-inhibited by short linear motifs (SLiMs) in its ...

Human pluripotent stem cells (hPSCs) exist in multiple, transcriptionally distinct states and serve as powerful models for studying human development. Despite their significance, the molecular ...

imageimageTranscriptome-wide measurement of subcellular mRNA dynamics in mouse ES cells reveals that nuclear retention is the rate-limiting step in the life-cycle of most mRNAs and provides a resource ...