A team of researchers from Academia Sinica and National Taiwan University has identified the Drosophila Cul2 substrate ...

Researchers at Tulane University, with a team of colleagues from eight other universities, have discovered a new nerve cell signaling mechanism that could transform our understanding of pain and lead ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, crucial for ...

The design of new calcium channels, built bottom-up from scratch, was reported last week in Nature. "Biochemists have been studying ion channels for decades and debating about how they work for almost ...

Wnt signaling pathways have many important roles in cells and are highly conserved across the animal kingdom from fruit flies to humans. In addition to Wnt signaling being involved in many processes ...

The global pandemic may be over, but SARS-CoV-2 continues to infect people around the world. Indeed, the United States has recorded roughly 750 deaths from COVID-19 over the past month. Now, an siRNA ...

The readout validates SpliSense' platform, supporting advancement of the Company's additional pulmonary programs, for muco-obstructive diseases and idiopathic pulmonary fibrosis, into the clinic in ...

A new paper published today in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key ...

Cystic fibrosis (CF) lung disease manifests through abnormally thick mucus, persistent bacterial infections and a dysregulated innate immune system that involves significant neutrophilic inflammation.

Sionna Therapeutics, Inc. has announced the presentation of promising preclinical data at the 48th European Cystic Fibrosis Conference in Milan, showing that its nucleotide-binding domain 1 (NBD1) ...

Scientists from the University of California, San Francisco (UCSF), have used deep learning techniques to design an approach for generating artificial proteins that can move and change shape much like ...

Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...