By reexamining 3D images used to map the connections between brain cells, researchers are uncovering new information about a small, elusive, and often overlooked cellular appendage.

Strikingly, the researchers also observed similar cilia defects in motor neurons from ALS patients with mutations in one of the most common genetic causes of ALS, C9orf72.

The primary cilia observed in this study originated from both animal and human beta cells. The researchers investigated how the skeletal structure (axoneme) formed from microtubules is organized.

The study "Effect of alpha-tubulin acetylation on the doublet microtubule structure" by S. Yang et al employs a multi-disciplinary approach, including cryo-electron microscopy (cryo-EM), molecular ...

Keywords: primary cilia, electrical oscillations, electrical antenna, polycystin-2, microtubules, axoneme Citation: Scarinci N, Gutierrez BC, Albarracín VH, Cantero MdR and Cantiello HF (2023) Role of ...

Cilia consist of an outer structure of nine pairs of microtubules, long tube like molecules that are part of the cell cytoskeleton, arranged into a circle.

Some cilia that had their membranes removed were subsequently examined to define the number and size of microtubules, other structural components repeating in such cilia, and chirality.

Cilia are small hair-like organelles that extend from cells and perform many functions, including motility and signaling. Researchers have now revealed that cilia have a specialized transport hub ...

Neuronal cilia contain synapses that signal for genomic alterations in the neuron nucleus, inducing long-term changes.

Cilia Are Minuscule Wonders, and Scientists Are Finally Figuring Out How to Mimic Them A new cilia-covered chip could revolutionize portable medical diagnosis By Saugat Bolakhe edited by Sophie ...

Cilia are cell-surface organelles with cytoskeletons formed by different microtubule types. These microtubules are decorated inside and out by proteins that alter microtubule stability and elasticity ...