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Objective: To describe the characterization of a novel deletion causing α-thalassemia. Methods: The proband was a 4-year-old boy who presented with abnormal hematological parameters identified during ...

The 'silent' X chromosome within female brains may not be so silent after all. A new study has found evidence in both mice and humans that as we age, 'sleeping' X chromosomes can be 'awakened' in ...

Chromosomal rearrangements resulting in an interstitial inverted duplication with concomitant terminal deletion were first described for the short arm of chromosome 8 in 1976. Since then, this type of ...

Frontiers Science Center for Molecular Design Breeding of the Ministry of Education, State Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding; Key ...

A risk factor is something that affects your chance of getting a disease, such as cancer. Different cancers have different risk factors. Some risk factors, like smoking, can be changed. Others, like a ...

5, 6 Given the requirement for dimerization for kinase activation, it is conceivable that the deletion mutants have a dominant-negative effect on the native BCR-ABL by formation of heterodimers ...