Researchers at National Taiwan University have uncovered, for the first time at atomic resolution, how the human proteasome ...

Highlighting 10 innovative late-stage BioPharma drugs with the potential to reshape treatment paradigms and industry dynamics ...

For more than 70 years, hydralazine has helped doctors lower dangerously high blood pressure during medical emergencies, ...

Background Hereditary haemorrhagic telangiectasia (HHT) and juvenile polyposis syndrome (JPS) can be caused by SMAD4 pathogenic variants. SMAD4 is a common transcription factor of the BMP/TGFβ ...

UNC researchers discovered how a key step in cell signaling works by showing exactly how G proteins detach from receptors ...

Could a 70-year-old high blood pressure medicine hold the secret to stopping one of the deadliest brain cancers? New research ...

Discover how strategic reductions in dietary protein can trigger powerful cellular repair pathways, lower pro-aging signals, ...

GPCRs (G protein-coupled receptors), also known as 7 transmembrane domain receptors, are the largest receptor family in the human genome, with ≈800 members. GPCRs regulate nearly every aspect of human ...

This useful study advances our understanding of how organisms respond to chronic oxidative stress. Using the nematode C. elegans, the authors identified key neuronal signaling molecules and their ...

The stock of Structure Therapeutics has dropped over 55% since my last review of this company last June, making it worth a fresh look after its big decline. The company’s lead asset, GSBR-1290, ...

Aaron T. Gerds, MD, discusses the unmet needs in the treatment of essential thrombocythemia, as well as novel methods for approaching disease treatment. In an interview, Aaron T. Gerds, MD, ...