Hemoglobin H disease (three gene defects): This form presents with moderate to severe anemia. "Symptoms often include chronic tiredness or fatigue, weakness, pale or yellowish skin due to jaundice ...

This is called alpha-thalassemia disease or hemoglobin H disease. Depending on the type of gene mutations a child inherits, symptoms can range from mild to severe. Hemoglobin Barts disease.

Alpha-thalassemia is one of the most common hemoglobin genetic abnormalities and is caused by the reduced or absent production of the alpha globin chains. Alpha-thalassemia is prevalent in ...

Spotlight On > ASH: Thalassemia Managing Non-Transfusion-Dependent Thalassemia Presents Challenges — Despite its name, non-transfusion-dependent thalassemia is not a mild form of the disease ...

Thalassemia is a genetic blood disorder that impacts the ability of the blood to get oxygen to the body’s organs. Learn about the signs, how it’s diagnosed & treated.

She had a history of non–transfusion-dependent α-thalassemia (hemoglobin H disease) complicated by acquired hemochromatosis. Her medical history was also notable for thrombocytopenia, which had ...

This hemoglobin, designated "I", migrated more rapidly than normal hemoglobin on filter-paper electrophoresis at pH 8.6, and constituted about 20 per cent of the total hemoglobin present.

The most well-known of these is sickle cell anemia (SCA). SCA is the most common genetic disease in the United States. About 1 in 12 African Americans carries the gene mutation that can lead to SCA.