Controlling regioselectivity remains one of the major challenges in hydrocyanation. When an unsymmetrical alkyne undergoes this reaction, it typically yields a mixture of regioisomers. This ...

Aberrations in fibroblast growth factor receptors FGFR2/3 are major drivers of many cancers-including intrahepatic ...

A systematic survey of archived protein structures has revealed dozens of examples of a previously overlooked covalent bonding motif. Mapping these nitrogen–oxygen–sulfur (NOS) linkages could open the ...

"Our results demonstrated that the combination of β-sheet amide hydrogen bond formation and metal cross-linking of side chains limits the number of possible isomers.

A research team has successfully developed a new approach to create switchable magnetic materials by using hydrogen bonding at the molecular level. This groundbreaking study shows how certain ...

Hydrogen is not a metal on Earth, but scientists keep trying to create metallic hydrogen under high pressure to unlock a new superconductor.

The halogen bonding motif combined with a good STD signal of a hydrogen atom directly adjacent to the halogen was used as the primary criterion for hit prioritization (Figure 2C). In addition, we ...

An inter-helical carboxylate-hydroxyl hydrogen-bond motif is present at functionally important sites of membrane proteins from archaea to the brain. External carboxylate-containing H-bond clusters are ...

A hydrogen bond is an electrostatic attraction between an atom and the positive charge of a hydrogen atom covalently bound to something else. It is weaker than a covalent bond and can be either ...