The 3.0 Å resolution crystal structure of Pariacoto virus (PaV) reveals extensive interactions between portions of the viral RNA genome and the icosahedral capsid. Under the protein shell of the ...

Departments of Mathematics, University of York, York YO10 5DD, U.K. Departments of Mathematics, University of York, York YO10 5DD, U.K. Department of Biology ...

Nantes Université, TaRGeT, Translational Research for Gene Therapies, CHU Nantes, INSERM, UMR 1089, F-44000 Nantes, France Nantes Université, CNRS, CEISAM, UMR 6230 ...

Ideally they form 280-member icosahedral clusters, (H 2 O) 280, (below), shown looking down the two-fold, three-fold, and five-fold axes of symmetry. Only the oxygen atoms of the constituent water ...

Beneath the Jyvaskylavirus capsid, the membrane vesicle follows icosahedral symmetry, although it also displays a high degree of sphericity (Figure 5A, left). This internal membrane vesicle encloses ...

To flip the ratio and bias an AAV away from toxic hotspots and towards a target organ or cell, researchers like Deverman, Gradinaru, and Davidson have developed capsid engineering strategies to put ...

Experiments suggest the capsid must be flexible to function; however, capsid structure and dynamics have not been thoroughly characterized in the absence of icosahedral symmetry constraints. Here, all ...