Therefore, it is critically important to understand whether insulin resistance affects all aspects of insulin action equally. Physiologically, the fact that the half-maximal effective ...

Type 2 diabetes is projected to afflict 300 million people worldwide by 2020. Therefore, a deeper understanding of the processes and mechanisms that lead to metabolic failure in key tissues and ...

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high morbidity and mortality worldwide. In affected people, insulin is unable to ...

Type 2 diabetes arises from a combination of impaired insulin action and defective pancreatic β-cell function. Classically, the two abnormalities have been viewed as distinct yet mutually ...

Insulin resistance is a growing health concern worldwide, linked to a variety of conditions such as type 2 diabetes, polycystic ovary syndrome (PCOS), Alzheimer's disease, metabolic syndrome, and ...

Now, a study published in Cell Communication and Signaling describes new molecular mechanisms to understand insulin resistance in skeletal muscle and to outline future drug targets for DM2.

Impaired cellular insulin signaling is the most understood mechanism, but it does not always accompany impaired insulin action, indicating other factors must be involved. The role of the SNS in ...

Exercise program improves insulin action in the brain. Download PDF Copy; ... They can also help clarify the underlying mechanisms. Source: Deutsches Zentrum fuer Diabetesforschung DZD.

Get Instant Summarized Text (Gist) New molecular mechanisms linked to insulin resistance in skeletal muscle have been identified, highlighting potential drug targets for type 2 diabetes.