A UPS cargo plane crashed shortly after takeoff from Louisville, Kentucky, erupting in flames and sending thick black smoke over the area. The McDonnell Douglas MD-11 aircraft was bound for Hawaii. Authorities confirmed at least three fatalities and multiple significant injuries,

A UPS plane crashed on takeoff from the airport in Louisville, Kentucky, igniting a huge fire on ground, officials said Tuesday.

The Federal Aviation Administration said the plane crashed at about 5:15 p.m.