As per the National Kidney Foundation, millions of people are suffering from kidney diseases and mostly because of irregular ...

The human body experiences various health problems because of inflammation, which can lead to joint pain, heart disease and ...

Discover the essential role of TGF-Beta 1 in cellular regulation, its signaling pathway, and how TGF-β1 antibodies are used ...

A new proteomic analysis is shedding a fresh light on the cytokine networks fueling idiopathic pulmonary fibrosis (IPF), ...

CNDP enzymes—carnosinase-1 (CNDP1) and carnosinase-2 (CNDP2)—are zinc-dependent metalloproteinases central to the metabolism of carnosine and related histidine-containing dipeptides. By maintaining ...

Scientific interest in cannabis has accelerated at an unprecedented pace, with 2025 producing more peer-reviewed research than any year on record. Across oncology, neurology, psychiatry, pain, ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Spinal muscular atrophy (SMA) is a ...

Background Pathogenic mutations in genes encoding components of the Ras/mitogen-activated protein kinase (Ras-MAPK) pathway cause RASopathy. Here, we describe five unrelated patients with SLE carrying ...

Skin aging manifests as structural degradation, functional decline, and heightened disease susceptibility. Central to this process is the overactivation of the mitogen-activated protein kinase (MAPK) ...

PAS-004 is being tested in a phase 1 trial for MAPK pathway-driven advanced solid tumors, with dosing initiated at 30 mg. The trial is multicenter, open-label, and dose-escalation, assessing safety, ...