News

Click chemistry PET imaging tracks antisense drug distribution in the brain
Assessing the distribution of a medication in the brain is critical for the treatment of a vast range of neurological ...
Experimental model enables study of how protein complex influences mitochondrial function
A study by the Center for Redox Processes in Biomedicine (Redoxoma) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil) presents a valuable new experimental model for investigating ...
Fierce Biotech1d
Pfizer expands AI-powered small-molecule discovery collab with XtalPi
XtalPi has accrued a number of Big Pharma partners over the years, including Eli Lilly, which struck a $250 million deal in 2023 to use XtalPi’s tech to identify potential drug candidates that Lilly ...
Beyond the crystal: Dynamic model captures loop flexibility in swine virus drug design
Porcine reproductive and respiratory syndrome virus (PRRSV) continues to devastate the global swine industry, yet the ...
News-Medical.Net7d
Experimental drug promotes weight loss by heating fat instead of suppressing appetite
An article published in the journal Nature Metabolism presents an experimental drug that stimulates adipose tissue cells to ...
Experimental drug holds promise for controlling weight and blood sugar
An article published in the journal Nature Metabolism presents an experimental drug that stimulates adipose tissue cells to ...
New Immunotherapy Reverses Cholesterol Damage in Heart Cells
A new antibody treatment prevents cholesterol buildup in heart mitochondria and restores energy production, offering hope for ...
Myosin makes the moves to keep cell processes humming along
The research, which has direct implications for how root systems manage responses to plant hormones, also has broader implications for understanding the condensation of other motile proteins that move ...
The EMBO Journal1mon
A structural inventory of native ribosomal ABCE1‐43S pre‐initiation complexes - The EMBO Journal
Isolated map and molecular model of the eIF3 PCI‐MPN core color coded as in Fig 2. Structural hallmarks are indicated, and a scheme shows the composition of the lobes. B, C. ... (PDB 5LL6, Heuer et al ...
GitHub1y
Contains code for the manuscript "Multiscale modeling shows how 2'-deoxy-ATP rescues ventricular function in heart failure" - GitHub
The molecular_analysis directory contains scripts and notebooks for performing molecular dynamics analysis, constructing and analyzing Markov State Models (MSM), and setting up and analyzing Brownian ...
C&EN1y
ATP-Concentration- and Force-Dependent Chemomechanical Coupling of Kinesin Molecular Motors | Journal of Chemical Information and Modeling - ACS Publications
A model is presented for the chemomechanical coupling of kinesin motors, which proposes that the rate constants of the chemical reaction are independent of the external force. On the basis of the ...
SciTech Daily2y
Scientists Discover a New Class of “Molecular Motors” - SciTechDaily
EEA1-Rab5 Molecular Motor. Motor proteins are remarkable molecular machines within a cell that converts chemical energy, stored in a molecule called ATP, into mechanical work. The most prominent ...