Plasmacytoid dendritic cells can be activated with viral and bacterial DNA via TLR9. Activated pDCs promote generation of both Th1/Th17 cells [46,76,87,92] and Tregs [104,105].

In this review, we will update the state-of-the-art of the lymphatic system in development and disease pathogenesis with a special focus on cardiovascular diseases. For lymphangiogenesis in cancer, ...

While surgery may still be an option once there is lung cancer metastasis to lymph nodes, body-wide treatments like chemotherapy or immunotherapy are often added to it. [3] Lung cancer that's in ...

N1 Single lymph node metastasis, 2 cm or less in greatest dimension N1 Single regional lymph node metastasis in the true pelvis (hypogastric, obturator, external iliac or presacral lymph node) N2 ...

This HLA-DR+CD15+CD16+ subset was positive for CD83, CD275 and, like plasmacytoid pDC, CD303+. However, in contrast to pDC it formed distinct t-SNE clusters and differed from reference pDC ...

Background and aims Aberrant and persistent production of type I interferon (IFN) is known to play a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE), and plasmacytoid dendritic ...

The lymph node stroma model offers a platform to test complex fluid flow and retention of T cells, which support the immune system and fight disease. The research also points to the importance of ...

Background and aims Plasmacytoid dendritic cells (pDC) are potent producers of IFNα, we investigated what additional soluble factors are produced by pDCs and the effect of pDC depletion with ...