As pyruvate was used as the denominator to calculate TCA cycle metabolite ratios, we extended our analysis to lactate since pyruvate is converted to lactate by lactate dehydrogenase. Cells in Cluster ...

How the TCA cycle takes place in hydrothermal environments is investigated by many approaches. Organic reactions may have initially used metals such as iron-containing minerals as redox catalysts in ...

Working model revealing the role of ALDH4A1 in maintaining an active MPC complex for mitochondrial pyruvate import and TCA cycle entry. Credit: Nature Cell Biology (2025). DOI: 10.1038/s41556-025 ...

PURPOSEThe tricarboxylic acid (TCA) cycle occurs within the mitochondrial matrix plays a critical role in mitochondrial metabolism, ... CPI-613 (devimistat), a novel systemic therapeutic that targets ...

The TCA cycle cannot remove pyruvate fast enough. This would mean that pyruvate would accumulate and this in turn would stop glucose breakdown… the result would be that we cannot produce ATP anymore ...

It’s through the Krebs cycle that we get energy from the food we eat. To grasp how the cycle works, it’s useful to remember what food is made of. Like everything else in the universe, the ...

Pantothenic acid is the precursor for coenzyme A (CoA; Hayflick, 2014), which is added to acetyl-CoA by the pyruvate dehydrogenase complex (PDHC; Patel and Korotchkina, 2006).Acetyl-CoA is an ...

AMSBIO has expanded its range of top quality, high-performance assay kits, antibodies, enzymes, and substrates for cellular metabolism research. Cell metabolism is the series of chemical synthesis ...

The Krebs cycle may be like a busy roundabout, as vehicles whizz in and out from different junctions Transformer: The deep chemistry of life and death Nick Lane Profile Books IF WE want to ...