EurekAlert!1d
How a critical enzyme keeps potentially dangerous genes in check
The new study reveals a remarkable way that cells keep us safe from transposable elements (TEs) gone wild. The researchers found that cells have taken advantage of an entire protein network to repress ...
PharmiWeb10d
Global Urea Cycle Disorder Treatment Market to Reach USD 771.0 Million by 2035, Expanding at a CAGR of 3.5% - Transparency Market Research, Inc.
The global industry was valued at US$ 527.5 Mn in 2024 and is projected to exceed US$ 771.0 Mn by 2035, growing at a CAGR of ...
eLife16d
Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression
Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...
Nature21d
The hemochromatosis C282Y allele: a risk factor for hepatic veno-occlusive disease after hematopoietic stem cell transplantation
The conditioning regimens were: busulfan 1 mg/kg orally every 6 h, days −7 through −4 (total dose 16 mg/kg) and cyclophosphamide 120 mg/kg by intravenous (i.v.) infusion over 3 days ...
Frontiers2mon
FGF21 ameliorates diabetic nephropathy through CDK1-dependently regulating the cell cycle
FGF21 has been shown to ameliorate diabetic nephropathy, and in addition FGF-21-treated mice impeded mitogenicity, whereas it is unclear whether FGF21 can influence DN progression by regulating the ...
Frontiers2y
Understanding gut-liver axis nitrogen metabolism in Fatty Liver Disease
Both increased ammonia production by gut microbiota and decreased ammonia hepatic removal due to impaired hepatic urea cycle activity or disrupted glutamine synthetase activity may contribute to ...