FDA fast track designation facilitates expedited development of DPTX3186, recognizing its potential to address serious unmet ...

School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, PR China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of ...

(A) The heatmap showing the differential expression of the Wnt proteins and the Wnt target genes between the GTEx cortex (n = 199) and TCGA-GBM (n = 173) datasets. (B) The spatial transcriptomic data ...

Abstract: Wnt signaling pathways play roles in many developmental processes such as, cell proliferation, differentiation, migration, and regulation of cell polarity. Disorders in Wnt/beta-catenin ...

ST316, a β-catenin/BCL9 antagonist, demonstrated safety, target engagement, and early antitumor activity in advanced solid tumors. ST316, a first-in-class antagonist of the interaction between ...

Hepatocellular carcinoma (HCC) is one of the deadliest cancers globally, with increasing incidence and mortality rates. It arises from chronic liver diseases, including hepatitis B or C infections, ...

Developing peptide-based tools to fine-tune growth signaling pathways, in particular molecules with exquisite selectivity and high affinities, opens up opportunities for cellular reprogramming in ...

ABSTRACT: Several recent scientific interventions have been conducted to investigate the effects of intermittent fasting (IF) on tumor metastasis. It is well known that IF has a positive effect on ...

Clinical determinants of survival in patients with stage II-III pancreatic cancer. Correlation of enriched specific subset of immune cells nearby tumor associated macrophage (TAM) with pathologic ...