Hepatocellular carcinoma (HCC) is the sixth leading cause of cancer-related mortality worldwide.1 Despite therapeutic ...

Type 1 diabetes (T1D) is an autoimmune disorder characterized by the specific destruction of insulin-producing pancreatic β-cells.

Parabilis Medicines, a clinical-stage biopharmaceutical company committed to creating extraordinary medicines for people living with cancer, today announced preliminary clinical data demonstrating the ...

This important study reports the development of the first tankyrase degrader and demonstrates its enhanced ability to inhibit β-catenin signaling compared to conventional tankyrase inhibitors. The ...

FDA fast track designation facilitates expedited development of DPTX3186, recognizing its potential to address serious unmet ...

Scientists may have just cracked the code behind gray hair—without dye, drugs, or genetics. A hidden flaw inside your hair follicles could be to blame, and researchers say it might be fixable.

FDA grants Fast Track designation to DPTX3186, Dewpoint’s first in class condensate modulator for gastric cancerDesignation provides increased FDA engagement, rolling review eligibility, and potential ...

Abstract: Wnt signaling pathways play roles in many developmental processes such as, cell proliferation, differentiation, migration, and regulation of cell polarity. Disorders in Wnt/beta-catenin ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Photodynamic therapy (PDT) resistance limits ...

Objective: This study examined the effects of Echinococcus multilocularis infection on the activation of the Wnt signaling pathway in hepatocytes, its association with epithelial-mesenchymal ...

ABSTRACT: Abnormal cell division leading to chromosomal instability is a hallmark of cancer development. Accurate chromosome classification Lysis plays an important role in cell division, and the ...