US and Iranian delegations will gather in Rome Saturday for a second round of high-level talks on Tehran’s nuclear program amid tempered optimism about a diplomatic way forward. Saturday’s negotiations come a week after an initial round was held in Muscat.

Iran and the United States are preparing for a second round of negotiations over Tehran’s rapidly advancing nuclear program in Rome.

Mr. Trump’s chief envoy to the talks, Steve Witkoff, has also sent mixed signals over what the United States wants. Over the past week, he has moved from suggesting Iran could have a limited nuclear program to saying Iran needed to fully dismantle it.