EBP1 is low in Alzheimer’s disease brains, hinting at human relevance. “Our study suggests that … preservation of functional EBP1 could be a therapeutic strategy for AD,” the authors noted. The ...

Lactylation is a reversible, covalent, post-translational modification of proteins. It occurs exclusively on lysine residues, where it influences protein structure, stability, localization, and ...

Butovsky believes xenon has potential as an AD treatment. A Phase 1 clinical trial of xenon at BWH is recruiting healthy elderly volunteers to test safety and effects on immune cells. “I hope this ...

Several types of RNA help regulate gene expression, and a number of these transcripts have been linked to Alzheimer’s disease. However, no one has comprehensively examined how the regulatory RNA ...

Missense mutations that derail SORL1 trafficking cause AD. Other variants shift AD risk in East Asians and Europeans. SORL1 dysfunction messes with endosomes in neurons, and with lysosomes in ...

Submit applications for this initiative using one of the following notices of funding opportunities (NOFOs) or any reissues of these announcements through the expiration date of this notice: ...

This grant is for an allocation of CZI’s GPU resource (minimum request of 96 GPU). This is an in-kind award; there are no cash funds, financial contributions, or fees of any kind associated with the ...

Some drugs can activate AMPK, most prominently metformin, which is approved for diabetes and being trialed in dementia. Less well-known is aldometanib, developed by Lin’s team, which blocks aldolase, ...

I thank you for your response, for its thoughtfulness and thoroughness. The first round of a debate is most useful for isolating the crux. I therefore kindly ask for one more public round. This would ...