Feb 10, 2026 · Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired stem-cell disorder that makes red blood cells — and often white blood cells and platelets — abnormally vulnerable to …

Jul 28, 2025 · As frontline partners, PCPs coordinate work-up, referrals, and lifestyle counseling in dyspnea. Review essential steps for early cardiopulmonary care.

Jul 28, 2025 · Orthopnea or paroxysmal nocturnal dyspnea are signs of heart failure that need further investigation.

Jan 18, 2024 · Paroxysmal nocturnal hemoglobinuria is a rare and serious blood disorder. These five things to know will help elucidate the signs, symptoms, and even a bit of confusion about its name.

Jan 22, 2024 · Dr Karl J. D'Silva reviews the treatment algorithm for thromboembolism, an important complication in patients with paroxysmal nocturnal hemoglobinuria.

Apr 23, 2024 · The factor D inhibitor danicopan has been approved for use in Europe for patients with paroxysmal nocturnal hemoglobinuria with residual hemolytic anemia on standard therapy.

Feb 5, 2025 · Other symptoms of PPCM are congestion — including dyspnea on exertion — orthopnea, and paroxysmal nocturnal dyspnea, according to a paper published in the Journal of the American …

Echocardiographic parameters were added individually to determine the importance of each echocardiographic finding controlling for dyspnea at rest.

Jan 11, 2024 · Dr Piatek discusses the importance of identifying and adequately managing residual anemia in patients with paroxysmal nocturnal hemoglobinuria on C5 inhibitor therapy.

Apr 9, 2025 · Drs Piña and Hsich discuss the FRESH-UP trial that challenged the dogma of fluid restriction in heart failure and provide practical strategies for optimizing medical therapy instead.