Quadriceps Inhibition After Total Knee Replacement After a total knee replacement, many patients notice that it’s hard to lift the leg or fully contract the thigh muscles (quadriceps) — even when they’re trying as hard as they can. . This happens because of something called arthrogenic muscle inhibition — basically, the knee joint swelling and pain interfere with the signals from your brain to your quadriceps. The muscle isn’t weak from lack of strength training — it’s shut down by the nervous s
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